Honoring the gift of a transplant means protecting and restoring health care coverage for non-invasive post-transplant diagnostic tests.

Organ transplantation is a crucial treatment for patients facing end-stage organ failure, but organs are among the scarcest medical resource, with over 100,000 people on waiting lists in the U.S. and an average of 17 who die each day waiting for an organ1. It is estimated that within the first year post-transplant, 1 in 3 lung transplants will fail, and within 5 years, 1 in 3 heart, and 1 in 5 kidney will fail, respectively 2,3,4 . To improve early detection of organ rejection, prolong the longevity of transplants, and improve patients’ lives, post-transplant surveillance is essential.

Non-invasive diagnostic blood tests like donor-derived cell free-DNA (dd-cfDNA) and gene expression profiling (GEP) have been adopted across major transplant centers as the standard of care to monitor a patient’s transplanted organ health and immune status. These are simple blood tests that allow clinicians to detect declining health in transplanted organs and intervene earlier to preserve the transplanted organ’s function. Additionally, these tests can help reduce or avoid the need for traditional tissue biopsy, which can be incredibly burdensome for patients—from the physical pain and complications they may endure to disruptions in their daily life, such as missing work and long commutes to the hospital center.

Unfortunately, innovations in non-invasive diagnostics have outpaced policies that ensure clinicians can use them as transplant surveillance tools and that a patient’s insurance provider will cover them.

In the wake of other progress in the transplant space, such as earlier availability of organs and mandated lifetime coverage of immunosuppressive drugs, the time is now to honor the gift of transplant by ensuring coverage for the non-invasive tests that can save lives.


  1. Organ Donation Statistics. Health Resources and Services Administration. (March 2023.) https://www.organdonor.gov/learn/organ-donation-statistics.

  2. Yusen, Roger D et al. “The Registry of the International Society for Heart and Lung Transplantation: Thirty-second Official Adult Lung and Heart-Lung Transplantation Report--2015; Focus Theme: Early Graft Failure.” The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation vol. 34,10 (2015): 1264-77.
    doi:10.1016/j.healun.2015.08.014.

  3. Wilhelm, Markus J. “Long-term outcome following heart transplantation: current perspective.” Journal of thoracic disease vol. 7,3 (2015): 549-51.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387387/.

  4. Sussell, Jesse et al. “The economic burden of kidney graft failure in the United States.” American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons vol. 20,5 (2020): 1323-1333. doi:10.1111/ajt.15750.